Designing refoldable model molecules

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Designing refoldable model molecules.

We report a numerical study of the design of lattice heteropolymers that can refold when the properties of only a few monomers are changed. If we assume that the effect of an external agent on a heteropolymer is to alter the interactions between its constituent monomers, our simulations provide a description of a simple allosteric transition. We characterize the free energy surfaces of the init...

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ژورنال

عنوان ژورنال: Physical Review E

سال: 2003

ISSN: 1063-651X,1095-3787

DOI: 10.1103/physreve.68.046703